AT1A Receptor in Hypertension

Grant number: 1029396 | Funding period: 2012 - 2015

Completed

Abstract

Angiotensin is important for normal regulation of blood pressure but is also involved in cardiovascular diseases. Interruption of angiotensin’s actions is a common treatment of these diseases. Functional deletion of angiotensin receptors decreases blood pressure. Surprisingly the site(s) in the body responsible for this decrease are not known. We will examine the role of angiotensin receptors in the brain in the control of blood pressure in health and in cardiovascular disease.

Related publications (7)

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Viscerosensory input drives angiotensin II type 1A receptor-expressing neurons in the solitary tract nucleus

DA Carter, H Guo, AA Connelly, JK Bassi, AY Fong, AM Allen, SJ McDougall

2018-02-01

Homeostatic regulation of visceral organ function requires integrated processing of neural and neurohormonal sensory signals. The ..

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Functional and neurochemical characterization of angiotensin type 1A receptor-expressing neurons in the nucleus of the solitary tract of the mouse

DA Carter, YT Choong, AA Connelly, JK Bassi, NO Hunter, N Thongsepee, IJ Llewellyn-Smith, AY Fong, SJ McDougall, AM Allen

2017-10-09

Angiotensin II acts via two main receptors within the central nervous system, with the type 1A receptor (AT<inf>1A</inf>R) most wi..

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Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension

C Menuet, S Le, B Dempsey, AA Connelly, JL Kamar, N Jancovski, JK Bassi, K Walters, AE Simms, A Hammond, AY Fong, AK Goodchild, S McMullan, AM Allen

2017-03-07

The etiology of hypertension, the world's biggest killer, remains poorly understood, with treatments targeting the established sym..

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Respiratory modulation of sympathetic nerve activity is enhanced in male rat offspring following uteroplacental insufficiency

C Menuet, ME Wlodek, AY Fong, AM Allen

2016-06-01

Sympathetic nerve activity to the cardiovascular system displays prominent respiratory-related modulation which leads to the gener..

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Angiotensin type 1A receptor expression in C1 neurons of the rostral ventrolateral medulla contributes to the development of angiotensin-dependent hypertension

N Jancovski, DA Carter, AA Connelly, E Stevens, JK Bassi, C Menuet, AM Allen

2014-12-01

New Findings: What is the central question of this study? This study addresses the mechanism by which deletion of angiotensin II t..

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Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis

C Menuet, CP Sevigny, AA Connelly, JK Bassi, N Jancovski, DA Williams, CR Anderson, IJ Llewellyn-Smith, AY Fong, AM Allen

2014-11-05

Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, y..

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Stimulation of angiotensin type 1A receptors on catecholaminergic cells contributes to angiotensin-dependent hypertension

N Jancovski, JK Bassi, DA Carter, YT Choong, A Connelly, TP Nguyen, D Chen, EV Lukoshkova, C Menuet, GA Head, AM Allen

2013-11-01

Hypertension contributes to multiple forms of cardiovascular disease and thus morbidity and mortality. The mechanisms inducing hyp..

University of Melbourne Researchers